Formulation Testing

Pre-Clinical Formulation Development

In pre-clinical pharmacokinetic (PK) and toxicokinetic (TK) studies, formulations play a critical role to ensure test articles completely dissolved for intravenous administration and properly absorbed for oral or other routes of administrations. Quintara Discovery has helped many companies in formulation development using different strategies based on the properties of new API. Our primary approaches are:

  • The evaluation of pH effect
  • Selection of co-solvents
  • Selection of surfactants
  • Complex formation using cyclodextrin or its derivatives
  • Lipid based formulations
  • Combinations of multiple strategies above

Quintara Discovery has a tiered screening approach for general formulation studies, as well as a more in-depth investigation when sufficient information about the compound properties is given.