RapidFire-MS Assays

Label-free technology using RapidFire MS/MS detection provides a simple platform for studying biomolecular interactions and complex signaling pathways without interference from spatial-interference, autofluorescent or quenching effects of labels. Endogenous targets and multi-component pathways can be explored in a cellular background that more closely reflects their natural environment. The RapidFire format allows one to study multiple pathways at once, making assay development less tedious and data more easily comparable.At Quintara Discovery, we can provide services and expert knowledge for assay development and integration into the client’s drug discovery programs. RapidFire-MS/MS technology for label-free detection of small molecules and metabolites is available for the following but not limited to such services.

  • Established assays for targets of tumor metabolism and epigenetic targets, such as isocitrate dehyrogenase (IDH), indoleamine 2, 3-dioxygenase (IDO) and protein deacetylase Sirtuin-1 (SIRT1).
  • Assay development services for new assays using RapidFire-MS/MS analysis can be provided.
  • Biomarker assays for metabolite detection in tissues for various disease models and metabolomics Studies

Available Service:

  • Custom-fit established assays
  • New Assay Development using RapidFire
  • Screening compounds for inhibition or activation of target activity
  • Biomarker detection assays in disease models