LogD
| LogD denotes the partition co-efficient of drug candidates in a lipophilic phase such as octanol and a hydrophilic phase like water.
The LogD value is valuable to predict many ADME properties such as solubility in buffers and gut, cellular permeability, the ability to penetrate the blood-brain barrier and the uptake into the intestine. |
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Assay MethodologyTest compounds are mixed with octanol and phosphate buffer. The relative drug concentrations in each phase is determined by LC-MS and the LogD is calculated. |
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